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Manchester United make the short trip to Premier League leaders Manchester City on Sunday buoyed by their recent record at the Etihad as Leeds begin a new era under Jesse Marsch.
Arsenal could take advantage of visits to the top two for the Hammers and United by moving into fourth with games in hand to come when they travel to Watford.
AFP Sport takes a look at some of the key talking points ahead of the weekend action.
Can City end United Etihad jinx?
Even though they are now indisputably the top dogs in Manchester, City have had real problems beating United on their own turf in recent years.
The Premier League champions have won just one of their past seven home games in all competitions against United — in sharp contrast to their impressive record at Old Trafford.
Both teams need the three points on Sunday, with leaders City seeking to keep Jurgen Klopp’s charging Liverpool at arm’s length and United’s top-four hopes looking shaky.
The fourth-placed Reds are just two points ahead of West Ham and Arsenal as they seek to secure Champions League qualification for next season, while the Gunners have three games in hand.
City, who tend to dominate possession, have been caught out in recent years by United’s pace on the break and Pep Guardiola will be wary of the threat posed by players such as Jadon Sancho and Marcus Rashford.
Marsch makes Leeds bow
New Leeds boss Jesse Marsch has two huge tasks — following in the footsteps of the hugely popular Marcelo Bielsa and tightening up a horrifically leaky defence.
Leeds have conceded an eye-watering 60 goals in the Premier League this season — five more than any other team.
They are just two points and two places above the relegation zone after four straight defeats under the sacked Argentine.
Leeds, who travel to Leicester on Saturday, conceded 20 goals in February alone in the Premier League — the most a side has ever shipped in a single month in the competition.
The American former RB Salzburg and RB Leipzig boss has expressed his “massive” admiration for Bielsa as he begins the task of saving the club from relegation.
Arsenal’s top-four chance
Arsenal, for so long a fixture in the Champions League under Arsene Wenger, have a golden chance to return to Europe’s top club competition after five seasons away.
Mikel Arteta’s side are favourites to seize fourth spot, which secures entry into the competition, after recovering strongly from a disastrous start to the season.
The Gunners slumped to the bottom of the Premier League table after losing their first three matches but have stormed up the table since.
Arsenal, who face relegation-threatened Watford on Sunday, will overtake United if they make the most of their games in hand.
Their three recent wins on the bounce have come despite a lack of resources up front following the departure of forward and Pierre-Emerick Aubameyang to Barcelona.
Fixtures (1500 GMT unless stated)
Saturday
Leicester v Leeds (1230), Aston Villa v Southampton, Burnley v Chelsea, Newcastle v Brighton, Norwich v Brentford, Wolves v Crystal Palace, Liverpool v West Ham (1730)
Sunday
Watford v Arsenal (1400), Manchester City v Manchester United (1630)
Monday
Tottenham v Everton (2000)
